Not really - since XDG decided to go for non-hidden files inside the XDG dirs. So you can't just set your XDG config dir to be your home dir, since all the app config folders will be non-hidden folders in your home dir. And setting up multiple XDG dirs to point to the same dir will probably cause even more havoc, if apps use the same file name with different meanings in different XDG dirs.
Many apps that claim to respect XDG…don't respect XDG fully and mix executables, config, temporary files, and persistent files in some combination of the spread of XDG directories.