Could you recommend some psychopharmacological treatments? I’m dealing with some flavor of this which is making my life difficult. I’m working with a neurologist, but I’m interested in your thoughts.
Diet is probably number one, sugar cravings caused by dopamine dysregulation and can also induce dopamine dysregulation causing a rather vicious cycle. Those most addicted to sugar are the most harmed by it.
Low Dose Naltrexone (LDN) is probably the most used and widely accepted med within the patient communities and due to having a rather mild side effect profile is a great place to start. Such side effects include really crazy dreams, insomnia, and nausea. The stronger the side effects the more likely it'll work and the negative side effects will go away in time.
I predominately use amitriptyline and modafinil but I don't have the gut comorbidities that would preclude the use of modafinil. I'm not familiar with alternatives to modafinil but a friend who previously had success with modafinil, until the gut issues became too much for him, switched to levosulpiride and he says that worked great. This appears to be counterintuitive for me but psychopharmacological meds are a tough one because they almost always have more than one receptor binding affinity and there is the interplay between ligands of different types and strengths as well as how the brain and body reacts with it. In general I prefer the weaker ligands than the stronger ones and don't try to over-optimize such that every day is good, I target 80% of them.
I basically looked up what books are used in that field and read a bunch of those; Stahl's Essential Psychopharmacology being one of the better ones. There are also books on dysautonomia but I don't know if there is a particular one I would recommend - the whole dysautonomia space is rather nebulous. My big takeaway from that is that is dysautonomia is super complex and hardly anyone understands it.